Active Protocols These protocols were designed and developed by the Radiation Therapy Oncology Group (RTOG) of the American College of Radiology (ACR). They are intended to be used only in conjunction with institution-specific IRB approval for study entry. No other use or reproduction is authorized by RTOG nor does RTOG assume any responsibility for unauthorized use of this protocol. Active Links Brain Tumor Protocols Endorsed Studies Breast Cancer Protocols Gynecologic Cancer Protocols Symptom Management/Cancer Prevention Protocols Head & Neck Cancer Protocols Gastrointestinal Cancer Protocols Lung Cancer Protocols Genitourinary Cancer Protocols Sarcoma Protocols Brain Tumor Protocols PDF FORMAT (Requires Acrobat Reader) MISCELLANEOUS SUMMARY OF CHANGES BROADCAST 0929 Phase II Recurrent GBM (Activation: 06/25/2010) Consent & 0929 Forms & Study Agent Shipment Form 0929 Changes 0929 Broadcast 0837/ACRIN 6689 Phase II GBM (Activation: 02/26/2010) Consent & 0837 Forms 0837 Changes 0837 Broadcast RTOG 0834/EORTC 26053_22054/ NCIC CTG CEC.1, Phase III Anaplastic Glioma (Activation: 07/22/09) www.ctsu.org IND Exemption & Staged Payment Schedule & Group-Specific Appendix for US Sites   0834 Broadcast 0825/ACRIN 6686 Phase III GBM (Activation: 04/15/2009) Consent & 0825 Forms & Infusion Reimbursement & Patient Brochure & Staged Payment Schedule 0825 Changes 0825 Broadcast 0627 Phase II GBM (Temporarily Closed to Accrual) Consent & 0627 Forms 0627 Changes 0627 Broadcast 0625/ACRIN 6677 Phase II GBM (Closed to Accrual) Consent & 0625 Forms& 0625/6677 Overview& 0625/6677 ITW & 0625/6677 CRS & 0625/6677 PSA 0625 Changes 0625 Broadcast 0614 Phase III Memantine/Placebo/WBRT (Closed to Accrual) Consent & 0614 Forms & Shipment Form & IND Exemption 0614 Changes 0614 Broadcast 0611 GBM VEGF/MMP (Closed to Accrual) Consent & 0611 Forms 0611 Changes 0611 Broadcast 0539 Phase II Meningioma (Activation: 06/19/2009) Consent & 0539 Forms & Newsletter & Summary & Patient Brochure 0539 Changes 0539 Broadcast 0525 Phase III GBM (Closed to Accrual) (No Investigator Brochure) Consent & 0525 Forms & Shipment Form (save as word.doc)& EORTC Information [PDF] & Patients Brochure [PDF]& NCCTG Information [PDF]& IND Exemption & MD Anderson Cancer Ctr & Training Procedure Letter & Neurocognitive Certification Worksheet 0525 Changes 0525 Broadcast 0513 Phase I/II GBM (Closed to Accrual) Consent & 0513 Forms 0513 Changes 0513 Broadcast 0424 Phase II Brain (Closed to Accrual) Consent & 0424 Forms & Shipment Form & Neurocognitive Testing Training Video 0424 Changes 0424 Broadcast 0420 Phase II (Closed to Accrual) Consent & 0420 Forms 0420 Changes 0420 Broadcast 0320 Phase III (Closed to Accrual) Consent & 0320 Forms & Shipment Form (save as word.doc)& Presentation & Summary 0320 Changes 0320 Broadcast 0227 Phase I/II (Closed to Accrual) Consent & 0227 Forms & Shipment Form (save as word.doc) 0227 Changes 0227 Broadcast BR-0131 Phase II (Closed to Accrual) Appendix IV & Consent & BR-0131 Forms BR-0131 Changes BR-0131 Broadcast 9813 Astrocytoma (Closed to Accrual) Consent & 9813 Forms & Investigator Brochures 9813 Changes 9813 Broadcast 9802 Low Grade Glioma (Closed to Accrual) 9802 Forms 9802 Changes 9802 Broadcast 9402 Oligodendroglioma (Closed to Accrual) Appendix IV 9402 Changes 9402 Broadcast Breast Cancer Protocols PDF FORMAT (Requires Acrobat Reader) MISCELLANEOUS SUMMARY OF CHANGES BROADCAST 1014 Phase II Partial Breast Re-Irradiation (Activation: 06/04/10) Consent & 1014 Forms 1014 Changes 1014 Broadcast NSABP B-39/RTOG 0413 (Activation: 3/21/05) Consent in English & Patient Entry Procedure [PDF] & Credentialing info [PDF] & Common Active Sites [XLS] & Fact Sheet [PDF] & Cosmesis digital photo resubmission memo [PDF] & Memo 12-12-06 [PDF] & Memo 12-22-06 [PDF] & Memo 12-08-09 [PDF] & Time ranges for QOL/cosmesis [PDF] 0413 changes [PDF] 0413 Broadcast 0319 Breast Phase I/II (Closed to Accrual) Appendix IV & Consent & 0319 Forms 0319 Changes 0319 Broadcast 9804 Breast DCIS (Closed to Accrual) App. IV | Diag. 1 | Diag. 2 & Consent & 9804 Forms & Investigator Summary 9804 Changes 9804 Broadcast 9702 Breast Tamoxifen (Closed to Accrual)   9702 Changes   9517 Breast Brachytherapy (Closed to Accrual) 9517 Forms 9517 Changes 9517 Broadcast Symptom Management/Cancer Prevention Protocols PDF FORMAT (Requires Acrobat Reader) MISCELLANEOUS SUMMARY OF CHANGES BROADCAST 0831 Phase III Tadalafil/Placebo Prostate (Temporarily Closed to Accrual) Consent & 0831 Forms IND Exemption & Study Agent Shipment Form   0831 Broadcast 0841 Depression Screening (Limited to CCOP institutions only) Consent & Application to Participate & SCID Module A & SCID Module B & SCID Module GHI & 0841 Forms 0841 Changes 0841 Broadcast 0631 Phase II/III Spine Mets (Activation: 08/07/09) Consent & 0631 Forms 0631 Changes 0631 Broadcast 0614 Phase III Memantine/Placebo/WBRT (Activation: 03/28/08) Consent & 0614 Forms & Shipment Form & IND Exemption 0614 Changes 0614 Broadcast 0537 Phase II/III Electroacustimulation/Pilocarpine (Activation 9/19/08) (Phase II closed; Phase III open to accrual) (Limited-institution study with pre-selected sites) Consent & 0537 Forms & Instructional slides & Exemption Notice & Appendix VI & Video & Codetron FAQ 0537 Changes 0537 Broadcast 0518 Phase III Prevent Osteo (Closed to Accrual) Consent & 0518 Forms & Shipment Form 0518 Changes 0518 Broadcast 0517 Palliation Bone Mets (Activation: 07/11/06) Consent & 0517 Forms & Dental Checklist & Shipment Form & Patient Brochure & Slide Set & Letter to Investigators [DOC] 0517 Changes 0517 Broadcast 0433 Phase III (Activation: 3/31/05) Consent   0433 Broadcast 0315 Phase III (Closed to Accrual) Consent & 0315 Timeline & 0315 Forms 0315 Changes 0315 Broadcast 0215 Prostate Cancer (Closed to Accrual) Consent & 0215 Forms 0215 Changes 0215 Broadcast 0127 Phase III NSCLC (Closed to Accrual: 11/5/09)       0123 Phase II Lung (Closed to Accrual) Consent & 0123 Forms 0123 Changes 0123 Broadcast 9604 Late Effects (LENT) (Closed to Accrual)   9604 Changes   Gastrointestinal Cancer Protocols PDF FORMAT (Requires Acrobat Reader) MISCELLANEOUS SUMMARY OF CHANGES BROADCASTS 0848 Phase III Pancreas (Activation: 11/17/09) Consent & 0848 Forms 0848 Changes 0848 Broadcast 0822 Phase II Rectal (Closed to Accrual) Consent & 0822 Forms & IND Exemption 0822 Changes 0822 Broadcast 0529 Ph II Anal Canal (Closed to Accrual) Consent & 0529 Forms 0529 Changes 0529 Broadcast 0438 Phase I Liver (Closed to Accrual) Consent & 0438 Forms 0438 Changes 0438 Broadcast 0436 Phase III Esophagus (Activation: 6/30/08) Consent & 0436 Forms & Shipment Form & Investigator Brochures & Patient Brochure & Slide Set & Newsletter 0436 Changes 0436 Broadcast 0247 Phase II Rectal (Closed to accrual) Consent & 0247 Forms 0247 Changes 0247 Broadcast 0246 Phase II (Closed to Accrual) Consent & 0246 Forms 0246 Changes 0246 Broadcast 9811 Anal Canal (Closed to Accrual) Appendix IV & Consent & 9811 Forms 9811 Changes 9811 Broadcast 9716 CALGB Esophagus (Closed to Accrual)   9716 Changes   9415 Colectomy (LP) (HP) (Closed to Accrual)   9415 Changes   Genitourinary Cancer Protocols PDF FORMAT (Requires Acrobat Reader) MISCELLANEOUS SUMMARY OF CHANGES BROADCASTS 0926 Phase II Bladder (Activation: 11/11/09) Consent & 0926 Forms & IND Exemption & Appendix VI [PDF] 0926 Changes 0926 Broadcast 0828 VisionTree Prostate (Closed to Accrual) Limited institution study with pre-selected sites. Consent 0828 Changes 0828 Broadcast 0815 Ph III Intermed Risk Prostate (Activation: 09/14/09) Consent & 0815 Forms & ACE-27 [PDF] 0815 Changes 0815 Broadcast 0712 Phase II Bladder (Activation: 12/9/2008) Consent & 0712 Forms & IND Exemption 0712 Changes 0712 Broadcast 0622 Phase II Prostate Samarium (Activation: 4/03/08) Consent & 0622 Forms & Shipment Form & IND Exemption & Samarium Release Form 0622 Changes 0622 Broadcast 0621 Phase II Prostate (Activation: 4/08/08) Consent & 0621 Forms & Shipment Form & IND Exemption 0621 Changes 0621 Broadcast 0612 Prostate DNA Microarray (Activation: 6/20/06) Consent 0612 Changes 0612 Broadcast 0534 Phase III Prostate. (Activation: 02/13/2008) Consent & 0534 Forms & IND Exemption 0534 Changes 0534 Broadcast 0526 Phase II Prostate Brachy (Activation: 5/11/07) Consent & 0526 Forms 0526 Changes 0526 Broadcast 0521 Phase III Prostate (Closed to Accrual) 1.5 Case Credits Consent & 0521 Forms Shipment Form & Tissue Consent 0521 Changes 0521 Broadcast 0524 Phase I/II Bladder (Activation: 7/26/05) Consent & 0524 Forms 0524 Changes 0524 Broadcast 0415 Phase III Prostate (Closed to Accrual) Consent & 0415 Forms & Tissue Consent 0415 Changes 0415 Broadcast 0321 Phase II Prostate (Closed to Accrual) Consent & 0321 Forms 0321 Changes 0321 Broadcast 0233 Bladder Cancer (Closed to Accrual) Consent & 0233 Forms 0233 Changes 0233 Broadcast 0232 Phase III Prostate (Activation: 6/11/03) Appendix IV & Consent & 0232 Forms & Patients Brochure 0232 Changes 0232 Broadcast 0126 Prostate (Closed to Accrual) Appendix IV & Consent & 0126 Forms & Tissue Consent 0126 Changes 0126 Broadcast P-0019 Prostate Brachy (Closed to Accrual) Appendix IV & Consent & 0019 Forms P-0019 Changes    9910 Prostate (Closed to Accrual) Appendix IV & Consent & 9910 Forms 9910 Changes 9910 Broadcast 9906 Bladder (Closed to Accrual) App. IV | App. VII 9906 Changes   9902 Prostate (Closed to Accrual) Appendix IV & Consent & 9902 Forms 9902 Changes 9902 Broadcast 9805 Prostate Implant (Closed to Accrual) Appendix IV & 9805 Forms     9706 Bladder (Closed to Accrual 6/1/99) Appendix IV 9706 Changes   9608 pN+ Prostate (Closed to Accrual)   9608 Changes   9601 Prostate +/- Casodex (Closed to Accrual) Appendix IV & Consent & 9601 Forms 9601 Changes 9601 Broadcast 9506 Bladder   9506 Changes 9506 Broadcast 9413 Pros/Adv. (Closed to Accrual) Appendix IV & 9413 Forms 9413 Changes 9413 Broadcast 9408 Prostate/Early (Closed to Accrual) Appendix IV & 9408 Forms 9408 Changes 9408 Broadcast 9406 Prostate (Closed to Accrual) 9406 Forms& Consent 9406 Changes 9406 Broadcast 9019 Prostate (Closed to Accrual)   9019 Changes 9019 Broadcast 8903 Phase III Bladder     8903 Broadcast 8531 Phase III Prostate (Closed to Accrual) 8531 Forms & Consent & Appendix VI 85-31 Changes 8531 Broadcast 9202 Phase III Prostate (Closed to Accrual) 9202 Forms & Appendix IV Gynecologic Cancer Protocols PDF FORMAT (Requires Acrobat Reader) MISCELLANEOUS SUMMARY OF CHANGES BROADCASTS 0921 Phase II Endometrial (Activation: 11/06/09) Consent & 0921 Forms 0921 Changes 0921 Broadcast 0724 Phase III Cervix (Activation: 09/16/09) Consent & 0724 Forms IND Exemption 0724 Broadcast 0418 Phase II IMRT (Closed to Accrual) Consent & 0418 Forms 0418 Changes 0418 Broadcast 0417 Phase II Cervix/Bevacizumab (Closed to Accrual) Consent & 0417 Forms 0417 Changes 0417 Broadcast Head & Neck Cancer Protocols PDF FORMAT (Requires Acrobat Reader) MISCELLANEOUS SUMMARY OF CHANGES BROADCASTS 0920 Ph III Post-Op Advanced H & N (Activation: 11/5/09) Consent & 0920 Forms & IND Exemption Form [pdf] & Shipment Form 0920 Changes 0920 Broadcast 0619 Phase II High-Risk Post-Op H&N (Closed to accrual) Consent & 0619 Forms & 0619 SASF & EKG Summary 0619 Changes 0619 Broadcast 0615 Phase II Nasopharyngeal (Closed to Accrual) Consent & 0615 Forms & AE Grading Tool 0615 Changes 0615 Broadcast 0522 Advanced H & N (Closed to Accrual) Consent & 0522 Forms & AE Grading Tool & Init Shipment Form & Resupply Shipment Form (save as word doc) & Medicare MD Info & Medicare Reimbursement 0522 Changes 0522 Broadcast 0514 H&N Cancer Tissue/Specimen Bank (Closed to accrual) Consent & 0514 Forms & Study Summary 0514 Changes 0514 Broadcast 0244 Phase II H & N (Closed to accrual) Appendix IV & Consent & 0244 Forms 0244 Changes 0244 Broadcast 0234 Phase II (Closed to Accrual) Consent & Shipment Form (save as word.doc) & 0234 Forms 0234 Changes 0234 Broadcast 0225 Nasopharyngeal (Closed to Accrual) Appendix IV & Consent & 0225 Forms 0225 Changes 0225 Broadcast 0129 Advanced H & N (Closed to Accrual) Appendix IV & Consent & 0129 Forms 0129 Changes 0129 Broadcast 0022 IMRT Oropharynx (Closed to Accrual) Appendix IV & Consent & 0022 Forms 0022 Changes 0022 Broadcast 9911 Rec. H & N (Closed to Accrual) Consent & 9911 Forms 9911 Changes   9903 H & N Epo (Closed to Accrual) Appendix IV & Consent & 9903 Forms 9903 Changes 9903 Broadcast 9614 Molecular Analysis (Closed to Accrual)   9614 Changes   9512 T2 Vocal Cord (Closed to Accrual) Appendix IV & 9512 Forms 9512 Changes   9501 Post-Op (Closed to Accrual) Appendix IV & 9501 Forms 9501 Changes   9111 Larynx (Closed to Accrual) Appendix IV & 9111 Forms 9111 Changes   9003 Multi/FX (Closed to Accrual) 9003 Forms 9003 Changes 9003 Broadcast Lung Cancer Protocols PDF FORMAT (Requires Acrobat Reader) MISCELLANEOUS SUMMARY OF CHANGES BROADCASTS 0937 Phase II ED-SCLC (Activation: 03/18/10) 0937 Forms & Consent 0937 Changes 0937 Broadcast 0915 Phase II SBRT (Activation: 09/03/09) 0915 Forms & Consent 0915 Changes 0915 Broadcast 0813 Phase I/II SBRT (Activation: 02/02/09) 0813 Forms & Consent & Application to participate & OAR avoid diagram [PPT]& Institution Guidelines [PDF] 0813 Changes 0813 Broadcast 0623 Phase II SCLC (Closed to Accrual) 0623 Forms & Consent & Study Agent Shipment Form & IND Exemption 0623 Changes 0623 Broadcast 0618 Phase II SBRT (Closed to Accrual) 2 Case Credits 0618 Forms & Consent 0618 Changes 0618 Broadcast 0617 ph III NSCLC (Activation: 11/27/07) 0617 Forms & Consent & Slide Set [PDF] & Patient Brochure & Study Agent Shipment Form & Newsletter 0617 Changes 0617 Broadcast CALGB 30610/RTOG 0538, phase III SCLC (Activation: 03/25/08) www.ctsu.org     0538 Broadcast 0515 NSCLC (Closed to Accrual) 0515 Forms & Consent 0515 Changes 0515 Broadcast 0324 Phase II Lung (Closed to Accrual) Consent & Shipment Form (save as word.doc) & 0324 Forms 0324 Changes 0324 Broadcast 0241 Lung (Closed to Accrual) Appendix IV & Consent & 0241 Forms 0241 Changes 0241 Broadcast 0239 Phase II Lung (Closed to Accrual) Appendix IV & Consent & 0239 Forms 0239 Changes 0239 Broadcast 0236 Stage I/II NSCLC (Closed to Accrual) Consent & 0236 Forms 0236 Changes 0236 Broadcast ACRIN 6668/RTOG 0235 (ACRIN-coordinated study) (Closed to Accrual) Patients Brochure 0235 Broadcast 0229 Phase II Lung (Closed to accrual) Consent & 0229 Forms 0229 Changes 0229 Broadcast 0214 Phase III (Closed to Accrual) Appendix IV & Consent & 0214 Forms & PCI Lung Slide Set 0214 Changes 0214 Broadcast 0213 Phase I/II (Closed to Accrual) Appendix IV & Consent & 0213 Resupply Request Form (save as word doc) & 0213 Forms 0213 Changes 0213 Broadcast 0212 Phase II/III (Closed to Accrual) Appendix V & Consent & 0212 Forms 0212 Changes 0212 Broadcast 0117 Phase I/II (Closed to Accrual) Appendix IV & Consent & 0117 Forms 0117 Changes 0117 Broadcast L-0015 NSCLC (Closed to Accrual)   L-0015 Changes L-0015 Broadcast 9511 Pleural Effusion (Closed to Accrual)   9511 Changes   9410 Induction Chemo (Closed to Accrual) Appendix IV     9309 N2 (HP) (Closed to Accrual) Appendix IV 9309 Changes   9105 Post Op Lung (Closed to Accrual)       Sarcoma Protocols PDF FORMAT (Requires Acrobat Reader) MISCELLANEOUS SUMMARY OF CHANGES BROADCASTS 0630 Sarcoma Phase II (Activation: 3/25/08) (Cohort A closed; Cohort B open to accrual) Consent & 0630 Forms 0630 Changes 0630 Broadcast 0330 Phase II (Closed) Consent & 0330 Forms 0330 Changes 0330 Broadcast 0132 Sarcoma (Closed to Accrual) Consent & Case Reimbursement& How to participate & 0132 Forms 0132 Changes 0132 Broadcast 9514 Sarcoma (Closed to Accrual) Appendix IV & 9514 Forms 9514 Changes