0611 Broadcast DATE: October 31, 2007 SUBJECT: RTOG 0611, Closure Closure RTOG 0611, "Urinary VEGF and MMP Levels in Patients Receiving Radiation Therapy for Glioblastoma Multiforme: Prospective Determination of a Predictive Value for Recurrence," will close to patient accrual at 5 PM EST today, because the study has met its accrual objective. Notice of this closure was previously broadcast on October 17, 2007. Please notify your affiliates who are not on e-mail. To share a comment or ask a question, access the Headquarters Information and Telephone Listing on the RTOG web site, www.rtog.org , under "Member Info," or call 1-800-227-5463, ext. 4189, which provides a menu to reach the Headquarters departments. If you would like to be added/removed from the RTOG broadcast list or wish to update your e-mail address, contact Michelle Buado at mbuado@phila.acr.org. Web registration is available 24/7. Information and instructions available at http://silver1.phila.acr.org/Clinical_RTOG/pgIndex.html DATE: October 17, 2007 SUBJECT: RTOG 0611, Closure Closure RTOG 0611, "Urinary VEGF and MMP Levels in Patients Receiving Radiation Therapy for Glioblastoma Multiforme: Prospective Determination of a Predictive Value for Recurrence," will close to patient accrual at 5 PM EST on October 31, 2007, because the study has met its accrual objective. Please notify your affiliates who are not on e-mail. To share a comment or ask a question, access the Headquarters Information and Telephone Listing on the RTOG web site, www.rtog.org, under "Member Info", or call 1-800-227-5463, ext. 4189, which provides a menu to reach the Headquarters departments. If you would like to be added or removed from the RTOG broadcast list or wish to update your e-mail address, contact Michelle Buado at mbuado@phila.acr.org Web registration is available 24/7. Information and instructions available at https://silver2.phila.acr.org/Clinical_RTOG/pgIndex.html DATE: June 20, 2007 SUBJECT: New Forms Available for Web-Based Electronic Data Submission WEB-BASED ELECTRONIC DATA SUBMISSION UPDATE: Web-Based Electronic Data Submission is now available for the following forms: RTOG 0418 - I1 & TF Forms RTOG 0513 - I1 Form RTOG 0529 - I1 & F2 Forms RTOG 0611 - I1 & F1 Forms Per previous Broadcasts, web-based data submission became mandatory as of May 14, 2007 for all forms available for web-entry for all cases enrolled through RTOG. A complete listing of forms available for web data submission is available at http://www.rtog.org/members/webreg.html For technical support with web data submission, please email websupport@phila.acr.org. Questions regarding information being collected on the forms should be directed to RTOG Data Management at 215-574-3214. Web registration is available 24/7. Information and instructions are at https://silver2.phila.acr.org/Clinical_RTOG/pgIndex.html DATE: June 7, 2007 SUBJECT: RTOG 0611, Amended Amended RTOG 0611, "Urinary VEGF and MMP Levels in Patients Receiving Radiation Therapy for Glioblastoma Multiforme: Prospective Determination of a Predictive Value for Recurrence," Amendment 1. The targeted sample size was increased to 200 patients. Please see the complete summary of changes at http://www.rtog.org/members/protocols/0611/summary_changes.html Sites can download a copy of the protocol for IRB review by accessing the RTOG web site at http://www.rtog.org/members/protocols/0611/0611.pdf NCI policy requires that the "Version Date" on the protocol title page reflect the date the amendment was submitted by RTOG to NCI; for clarity, the broadcast date is provided in parentheses. Per CTMB Guidelines, amendments must be submitted and approved by local IRBs within 90 days. Expedited review is allowed; however, site IRB requirements take precedence. Please notify your affiliates that are not on e-mail. To share a comment or ask a question, access the Headquarters Information and Telephone Listing on the RTOG web site, www.rtog.org, under "Member Info", or call 1-800-227-5463, ext. 4189, which provides a menu to reach the Headquarters departments. If you would like to be added or removed from the RTOG broadcast list or wish to update your e-mail address, contact Michelle Buado at mbuado@phila.acr.org Web registration is available 24/7. Information and instructions available at https://silver2.phila.acr.org/Clinical_RTOG/pgIndex.html DATE: May 30, 2007 SUBJECT: RTOG 0611, sample size to increase ATTENTION INVESTIGATORS: Pending approval from CTEP, the sample size will be increased for RTOG 0611, "Urinary VEGF and MMP Levels in Patients Receiving Radiation Therapy for Glioblastoma Multiforme: Prospective Determination of a Predictive Value for Recurrence." Please continue to enroll your eligible patients. Please notify your affiliates who are not on e-mail. To share a comment or ask a question, access the Headquarters Information and Telephone Listing on the RTOG web site, www.rtog.org, under "Member Info", or call 1-800-227-5463, ext. 4189, which provides a menu to reach the Headquarters departments. If you would like to be added or removed from the RTOG broadcast list or wish to update your e-mail address, contact Michelle Buado at mbuado@phila.acr.org Web registration is available 24/7. Information and instructions available at https://silver2.phila.acr.org/Clinical_RTOG/pgIndex.html DATE: May 4, 2006 SUBJECT: RTOG 0611, Updated Updated RTOG 0611, "Urinary VEGF and MMP Levels in Patients Receiving Radiation Therapy for Glioblastoma Multiforme: Prospective Determination of a Predictive Value for Recurrence," has been updated as follows: Entire Protocol-Repaginated to conform with RTOG pagination standards; Eligibility Checklist-Protocol number added; Section 12.1-A5 deleted; Appendix I-"Genetic" changed to "protein." Please see the complete summary of changes at: http://www.rtog.org/members/protocols/0611/summary_changes.html The updated protocol can be accessed on the RTOG website at: http://www.rtog.org/members/protocols/0611/0611.pdf NOTE: These updates are editorial/administrative changes to the protocols. NCI requires that these changes be documented on the protocol title page as "Update Date," not as an amendment. IRB review is not required; however, these changes must be reported to site IRBs. To share a comment or ask a question, access the Headquarters Information and Telephone Listing on the RTOG web site, www.rtog.org, under "Member Info", or call 1-800-227-5463, ext. 4189, which provides a menu to reach the Headquarters departments. If you would like to be added/removed from the RTOG broadcast list or wish to update your e-mail address, contact David Corrie at dcorrie@phila.acr.org Web registration is available 24/7. Information and instructions are at https://silver2.phila.acr.org/Clinical_RTOG/pgIndex.html DATE: February 02, 2006 SUBJECT: RTOG 0611, Activated Activated RTOG 0611, "Urinary VEGF and MMP Levels in Patients Receiving Radiation Therapy for Glioblastoma Multiforme: Prospective Determination of a Predictive Value for Recurrence." Please note that this trial is a correlative study for patients enrolled on RTOG glioblastoma treatment protocols. Patients enrolled on RTOG 0525 are eligible to be enrolled on RTOG 0611 as well. You may download a copy of the protocol for IRB review by accessing the RTOG website at http://www.rtog.org/members/protocols/0611/0611.pdf Forms for this study also are available on the RTOG website at http://www.rtog.org/members/forms/0611/main.html Regulatory Notes: NCI policy requires that the "Version Date" of the protocol reflect the date that the protocol was submitted by RTOG to NCI; therefore, the version date and the activation date on the protocol title page are not the same. The "Update Date" (the same as the activation date) indicates that minor administrative changes were made to the protocol after NCI approval; these changes are detailed in a summary of changes that can be accessed at http://www.rtog.org/members/protocols/0611/summary_changes.html Please notify your affiliates that are not on e-mail. To share a comment or ask a question, access the Headquarters Information and Telephone Listing on the RTOG website, www.rtog.org, under "Member Info", or call 1-800-227-5463, ext. 4189, which provides a menu to reach the Headquarters departments. If you would like to be added/removed from the RTOG broadcast list or wish to update your e-mail address, contact David Corrie at dcorrie@phila.acr.org Web registration is available 24/7. Information and instructions available at https://silver1.phila.acr.org/Clinical_RTOG/pgIndex.html